![]() Some women may still have a reaction on this type and then it’s worth discussing changing the dose, the way you take it or the number of days you take it, with your doctor, to see if you can improve any symptoms of intolerance. It is the preferable one to take – especially if you are intolerant to progesterone. ![]() Micronised progesterone (known as Utrogestan in the UK) is a capsule that you swallow and is body identical. You are less likely to get a negative reaction if the progesterone you take is body identical. Systemic progesterone – absorbed by the whole body Unfortunately, progesterone (or a progestogen) intolerance symptoms are a very common reason why women decide to stop taking their HRT, as the progestogen (or progesterone) part can make them feel so dreadful. Some women show signs of intolerance to all types of progesterone, including what is released naturally by their ovaries. Some women react to certain types of progesterone/progestogen but don’t react the same way to other types. You may notice you feel worse for the two weeks you take progesterone or notice a change when you first start taking it continuously. ![]() If it has been more than 6 to 12 months since your last period, you will usually take progesterone (or a progestogen) continuously, with no breaks. This is where you take progesterone for two weeks and then have a twoweek break from taking it, to allow your womb to bleed for a few days, as this keeps the lining healthy. If you had a period within the last 6 to 12 months, you will usually be given a cyclical regime of progesterone (or a progestogen). This is to counteract the effect of the estrogen, keep the lining of the womb thin and healthy, and minimise the risk of the cells in the lining turning cancerous. Most women need to take a form of progesterone if they are taking replacement estrogen and still have their womb. It is worth noting that these risks are very small, and your actual risk of such diseases depends much more on your overall health, genetics, weight, and lifestyle habits. Synthetic progestogens have been found to have a small risk of blood clot, heart disease and breast cancer. There are also more risks associated with progestogens than progesterone. Symptoms of intolerance are much more common with synthetic progestogens. Progestogen, however, is synthetic (created chemically and structurally different to progesterone) and is the type that is used in all forms of contraception. It is derived from the yam root vegetable. Progesterone is body identical, meaning it’s identical in structure to the natural progesterone hormone produced by your ovaries. There are two main types of progesterone: progesterone and progestogen. ![]() Types of progesterone and associated risks Symptoms of progestogen intolerance affect around 10-20% of women and it’s often seen in women who use contraception such as the combined pill, the minipill, an IUS (coil), or in women who take some types of HRT. Progesterone does not usually have these effects. Metabolic reactions are when progestogens have a negative effect on systems that produce or regulate cholesterol, blood pressure and blood sugar levels. Physical consequences of progesterone intolerance can be acne, greasy skin, abdominal cramping or bloating, fluid retention, fatigue, headaches, dizziness, and breast tenderness. Possible psychological effects are anxiety, irritability, aggression, restlessness, panic attacks, low mood, poor concentration, forgetfulness, and heightened emotions. Some types of progestogens are known to cause more physical or metabolic side effects, while other types are associated with more psychological reactions. Symptoms of progesterone intolerance can be grouped into 3 main areas – psychological, physical and metabolic. The body reacts to the progesterone or progestogen, causing symptoms that can be similar to premenstrual syndrome. Progesterone intolerance is when you are particularly sensitive to the hormone progesterone or most likely it’s synthetic form, progestogen. Progesterone intolerance Factsheet Download factsheet
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